Endocrine Abstracts

The importance of thyroid hormones in neurological development has been well documented in both animals and humans. Thyroid hormones deficit during fetal development can have irreversible adverse effects on an individual’s neurological function; including mental retardation, deafness, and spasticity. The only source of thyroid hormones for the developing brain in early pregnancy is from the mother. There is a growing body of epidemiological and experimental evidence to su...

Mouse embryonic stem (ES) cells are pluripotent cells derived from preimplantation embryo. In culture these cells can differentiate into a broad variety of cell types, such as nerve, muscle heart, blood cells and islet cells. This capacity for multilineage differentiation is retained during genetic manipulation and in vitro propagation. This has stimulated interest in the isolation of analogous cells of human origin. Such human pluripotent cells would constitute a renewable so...

Objective: To evaluate the associations between nonalcoholic fatty liver disease (NAFLD) and atherosclerosis.Methods and Results: A total of 8971 participants aged 40 years and older from Baoshan district, Shanghai were included in the present study. The presence of NAFLD was evaluated by ultrasonography. Carotid intima-media thickness (CIMT) and brachial-ankle pulse wave velocity (ba-PWV) were measured in each participant. The prevalence of NAFLD was 30...

Background: The incidence of germline pathogenic/likely pathogenic variants (P/LPV) is relatively well described in low grade well differentiated neuroendocrine tumors (NETs). However, germline findings in G3 NENs including grade 3 NETs (G3NET) and poorly differentiated neuroendocrine carcinoma (NEC) is gravely understudied, and guidance related to germline testing in G3NEN is lacking.Methods: An IRB approved, single institution, retrospective chart revi...

Background: Germline pathogenic or likely pathogenic (P/LP) variants occur in approximately 10% of NEN patients with recent data suggesting a higher frequency in pancreatic NENs or paraganglioma/pheochromocytoma (PPGL). However, identification of VUS can complicate interpretation of germline results, particularly when diverse populations are under study and the optimal gene panel size for testing remains unclear.Methods: A single-center retrospective cha...